CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens

BACKGROUND: Antimicrobial peptides are important components of the host defence with a broad range of functions including direct antimicrobial activity and modulation of inflammation. Lack of cathelin-related antimicrobial peptide (CRAMP) was associated with higher mortality and bacterial burden and...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Kress, Eugenia, Merres, Julika, Albrecht, Lea-Jessica, Hammerschmidt, Sven, Pufe, Thomas, Tauber, Simone C., Brandenburg, Lars-Ove
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602852/
https://ncbi.nlm.nih.gov/pubmed/28915816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-017-0190-1
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