Searching Novel Therapeutic Targets for Scleroderma: P2X7-Receptor Is Up-regulated and Promotes a Fibrogenic Phenotype in Systemic Sclerosis Fibroblasts

Objectives: Systemic sclerosis (SSc) is a connective tissue disorder presenting fibrosis of the skin and internal organs, for which no effective treatments are currently available. Increasing evidence indicates that the P2X7 receptor (P2X7R), a nucleotide-gated ionotropic channel primarily involved...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Gentile, Daniela, Lazzerini, Pietro E., Gamberucci, Alessandra, Natale, Mariarita, Selvi, Enrico, Vanni, Francesca, Alì, Alessandra, Taddeucci, Paolo, Del-Ry, Silvia, Cabiati, Manuela, Della-Latta, Veronica, Abraham, David J., Morales, Maria A., Fulceri, Rosella, Laghi-Pasini, Franco, Capecchi, Pier L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602350/
https://ncbi.nlm.nih.gov/pubmed/28955239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00638
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