Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo

Lysosomal cysteine peptidase cathepsin B, involved in multiple processes associated with tumor progression, is validated as a target for anti-cancer therapy. Nitroxoline, a known antimicrobial agent, is a potent and selective inhibitor of cathepsin B, hence reducing tumor progression in vitro and in...

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Publicado en:Oncotarget
Autores principales: Mitrović, Ana, Sosič, Izidor, Kos, Špela, Tratar, Urša Lampreht, Breznik, Barbara, Kranjc, Simona, Mirković, Bojana, Gobec, Stanislav, Lah, Tamara, Serša, Gregor, Kos, Janko
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601720/
https://ncbi.nlm.nih.gov/pubmed/28938624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19296
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