Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors

[Image: see text] The predominant expression of phosphoinositide 3-kinase δ (PI3Kδ) in leukocytes and its critical role in B and T cell functions led to the hypothesis that selective inhibitors of this isoform would have potential as therapeutics for the treatment of allergic and inflammatory diseas...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Hoegenauer, Klemens, Soldermann, Nicolas, Zécri, Frédéric, Strang, Ross S., Graveleau, Nadege, Wolf, Romain M., Cooke, Nigel G., Smith, Alexander B., Hollingworth, Gregory J., Blanz, Joachim, Gutmann, Sascha, Rummel, Gabriele, Littlewood-Evans, Amanda, Burkhart, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601375/
https://ncbi.nlm.nih.gov/pubmed/28947947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00293
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