Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes

[Image: see text] We have discovered a novel series of isothiazole-based phenylpropanoic acids as GPR120 agonists. Extensive structure–activity relationship studies led to the discovery of a potent GPR120 agonist 4x, which displayed good EC(50) values in both calcium and β-arrestin assays. It also p...

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izdano v:ACS Med Chem Lett
Main Authors: Zhang, Xuqing, Cai, Chaozhong, Sui, Zhihua, Macielag, Mark, Wang, Yuanping, Yan, Wen, Suckow, Arthur, Hua, Hong, Bell, Austin, Haug, Peter, Clapper, Wilma, Jenkinson, Celia, Gunnet, Joseph, Leonard, James, Murray, William V.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601374/
https://ncbi.nlm.nih.gov/pubmed/28947942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00233
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