Decreased Taxon-Specific IgA Response in Relation to the Changes of Gut Microbiota Composition in the Elderly

Gut microbiota is known to change with aging; however, the underlying mechanisms have not been well elucidated. Immunoglobulin A (IgA) is the dominant class of antibody secreted by the intestinal mucosa, and are thought to play a key role in the regulation of the gut microbiota. T cells regulate the...

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Udgivet i:Front Microbiol
Main Authors: Sugahara, Hirosuke, Okai, Shinsaku, Odamaki, Toshitaka, Wong, Chyn B., Kato, Kumiko, Mitsuyama, Eri, Xiao, Jin-Zhong, Shinkura, Reiko
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601059/
https://ncbi.nlm.nih.gov/pubmed/28955323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.01757
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