Structural enzymology and inhibition of the bifunctional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis

Two valid targets for antibiotic development, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS), catalyze consecutive reactions in folate biosynthesis. In Francisella tularensis (Ft), these two activities are contained in a single protein, FtHPPK-DHPS. Wh...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:FEBS J
Hlavní autoři: Shaw, Gary X., Li, Yue, Shi, Genbin, Wu, Yan, Cherry, Scott, Needle, Danielle, Zhang, Di, Tropea, Joseph E., Waugh, David S., Yan, Honggao, Ji, Xinhua
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600157/
https://ncbi.nlm.nih.gov/pubmed/24975935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12896
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky