Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin States

Sex-dependent pituitary growth hormone (GH) secretory profiles—pulsatile in males and persistent in females—regulate the sex-biased, STAT5-dependent expression of hundreds of genes in mouse liver, imparting sex differences in hepatic drug/lipid metabolism and disease risk. Here, we examine transcrip...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Lau-Corona, Dana, Suvorov, Alexander, Waxman, David J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599723/
https://ncbi.nlm.nih.gov/pubmed/28694329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00301-17
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