NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells

Tissue stem cells are maintained in quiescence under physiological conditions but proliferate and differentiate to replenish mature cells under stressed conditions. The KEAP1-NRF2 system plays an essential role in stress response and cytoprotection against redox disturbance. To clarify the role of t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Murakami, Shohei, Suzuki, Takuma, Harigae, Hideo, Romeo, Paul-Henri, Yamamoto, Masayuki, Motohashi, Hozumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599717/
https://ncbi.nlm.nih.gov/pubmed/28674188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00086-17
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