PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance

Leptin signaling in the hypothalamus plays a crucial role in the regulation of body weight. Leptin resistance, in which leptin signaling is disrupted, is a major obstacle to the improvement of obesity. We herein demonstrated that protein tyrosine phosphatase receptor type J (Ptprj) is expressed in h...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Shintani, Takafumi, Higashi, Satoru, Suzuki, Ryoko, Takeuchi, Yasushi, Ikaga, Reina, Yamazaki, Tomomi, Kobayashi, Kenta, Noda, Masaharu
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599550/
https://ncbi.nlm.nih.gov/pubmed/28912580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12070-7
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