Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3

Spinocerebellar ataxia type 3 (SCA3) is caused by the expansion of a polyglutamine (polyQ) repeat in the protein ataxin-3 which is involved in susceptibility to mild oxidative stress induced neuronal death. Here we show that caffeic acid (CA) and resveratrol (Res) decreased reactive oxygen species (...

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Publicado no:Sci Rep
Main Authors: Wu, Yu-Ling, Chang, Jui-Chih, Lin, Wei-Yong, Li, Chien-Chun, Hsieh, Mingli, Chen, Haw-Wen, Wang, Tsu-Shing, Liu, Chin-San, Liu, Kai-Li
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599504/
https://ncbi.nlm.nih.gov/pubmed/28912527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11839-0
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