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A Phase II study of Ganetespib as second- or third-line therapy for metastatic pancreatic cancer
OBJECTIVES: Heat shock protein 90 (HSP90) regulates multiple signaling proteins involved in key pathways of pancreatic cancer pathogenesis. Ganetespib binds to HSP90 and interferes with its binding to client proteins thus leading to inactivation and degradation of the signaling proteins that promote...
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| Publicado en: | Am J Clin Oncol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5599313/ https://ncbi.nlm.nih.gov/pubmed/28301350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COC.0000000000000377 |
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