Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironment

We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single cell gene expression profiles to define three tumor-intrinsic transcriptional subtypes designated as proneural, mesenchymal, and classical. Transcriptomic subtype multiplicity correlated with increased intratumoral heterog...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Wang, Qianghu, Hu, Baoli, Hu, Xin, Kim, Hoon, Squatrito, Massimo, Scarpace, Lisa, deCarvalho, Ana C., Lyu, Sali, Li, Pengping, Li, Yan, Barthel, Floris, Cho, Hee Jin, Lin, Yu-Hsi, Satani, Nikunj, Martinez-Ledesma, Emmanuel, Zheng, Siyuan, Chang, Edward, Sauvé, Charles-Etienne Gabriel, Olar, Adriana, Lan, Zheng D., Finocchiaro, Gaetano, Phillips, Joanna J., Berger, Mitchel S., Gabrusiewicz, Konrad R., Wang, Guocan, Eskilsson, Eskil, Hu, Jian, Mikkelsen, Tom, DePinho, Ronald A., Muller, Florian, Heimberger, Amy B., Sulman, Erik P., Nam, Do-Hyun, Verhaak, Roel G.W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599156/
https://ncbi.nlm.nih.gov/pubmed/28697342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.06.003
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