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A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms

Modelling ionic channels represents a fundamental step towards developing biologically detailed neuron models. Until recently, the voltage-gated ion channels have been mainly modelled according to the formalism introduced by the seminal works of Hodgkin and Huxley (HH). However, following the contin...

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Библиографические подробности
Опубликовано в: :PLoS Comput Biol
Главные авторы: Balbi, Pietro, Massobrio, Paolo, Hellgren Kotaleski, Jeanette
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599066/
https://ncbi.nlm.nih.gov/pubmed/28863150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005737
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