5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells

Mammalian genomes contain several dozens of large (>0.5 Mbp) lineage-specific gene loci harbouring functionally related genes. However, spatial chromatin folding, organization of the enhancer-promoter networks and their relevance to Topologically Associating Domains (TADs) in these loci remain po...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Poterlowicz, Krzysztof, Yarker, Joanne L., Malashchuk, Igor, Lajoie, Brian R., Mardaryev, Andrei N., Gdula, Michal R., Sharov, Andrey A., Kohwi-Shigematsu, Terumi, Botchkarev, Vladimir A., Fessing, Michael Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599062/
https://ncbi.nlm.nih.gov/pubmed/28863138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006966
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