Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts

BACKGROUND: Lung fibroblasts are involved in extracellular matrix homeostasis, which is mainly regulated by transforming growth factor-beta (TGF-β), and are therefore crucial in lung tissue repair and remodeling. Abnormal repair and remodeling has been observed in lung diseases like COPD. As miRNA l...

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Veröffentlicht in:PLoS One
Hauptverfasser: Ong, Jennie, Timens, Wim, Rajendran, Vijay, Algra, Arjan, Spira, Avrum, Lenburg, Marc E., Campbell, Joshua D., van den Berge, Maarten, Postma, Dirkje S., van den Berg, Anke, Kluiver, Joost, Brandsma, Corry-Anke
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599028/
https://ncbi.nlm.nih.gov/pubmed/28910321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183815
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