Gymnemasylvestre derived compounds inhibit GSH depletion and increase cGMP and nitric oxide to attenuate advanced glycation end products induced hypertrophic growth in renal tubular epithelial cells

The accumulation of advanced glycation end products (AGE) plays significant role in developing tubular hypertrophy during diabetic nephropathy (DN). Reactive oxygen species and nitric oxide (NO) are directly involved in the progression of DN. We have studied the effect of standardized Gymnemasylvest...

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Veröffentlicht in:Toxicol Rep
Hauptverfasser: Vidyashankar, Satyakumar, Babu, Uddagiri Venkanna, Patki, Pralhad Sadashiv
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5598397/
https://ncbi.nlm.nih.gov/pubmed/28962295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2014.08.015
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