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Crx-L253X Mutation Produces Dominant Photoreceptor Defects in TVRM65 Mice
PURPOSE: The cone-rod homeobox (CRX) transcription factor is essential for photoreceptor gene expression, differentiation, and survival. Human CRX mutations can cause dominant retinopathies of varying onset and phenotype severity. In animal models, dominant frameshift Crx mutations introduce a prema...
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| Udgivet i: | Invest Ophthalmol Vis Sci |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Association for Research in Vision and Ophthalmology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5597032/ https://ncbi.nlm.nih.gov/pubmed/28903150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22075 |
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