Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells

A majority of patients with BRAF-mutated metastatic melanoma respond to therapy with BRAF inhibitors (BRAFi), but relapses are common owing to acquired resistance. To unravel BRAFi resistance mechanisms we have performed gene expression and mass spectrometry based proteome profiling of the sensitive...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Main Authors: Azimi, Alireza, Tuominen, Rainer, Costa Svedman, Fernanda, Caramuta, Stefano, Pernemalm, Maria, Frostvik Stolt, Marianne, Kanter, Lena, Kharaziha, Pedram, Lehtiö, Janne, Hertzman Johansson, Carolina, Höiom, Veronica, Hansson, Johan, Egyhazi Brage, Suzanne
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596587/
https://ncbi.nlm.nih.gov/pubmed/29048432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.406
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