CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response

Tumor suppressor genes play a key role in cancer pathogenesis. Through massive expression profiling we identified CHAC2 as a frequently downregulated gene in gastric and colorectal cancers. Immunohistochemistry and western blot revealed that CHAC2 was downregulated in most tumor tissues, and 3-year...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Liu, Shuiping, Fei, Weiqiang, Shi, Qinglan, Li, Qiang, Kuang, Yeye, Wang, Chan, He, Chao, Hu, Xiaotong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596586/
https://ncbi.nlm.nih.gov/pubmed/28837156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.405
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