Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines

Glioblastoma multiforme (GBM) is the most prevalent form of malignant brain tumor. Amlexanox, a novel compound, has been shown to have anti-cancer potential. In this study, the anti-tumoral effects and the underlying mechanisms of amlexanox were investigated. Amlexanox significantly suppressed proli...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Liu, Yang, Lu, Jie, Zhang, Zhimeng, Zhu, Lin, Dong, Shicai, Guo, Gaochao, Li, Ruohong, Nan, Yang, Yu, Kai, Zhong, Yue, Huang, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596579/
https://ncbi.nlm.nih.gov/pubmed/29048430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.396
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