Discovery of (4-bromophenyl)(3-hydroxy-4-methoxyphenyl)methanone through upregulating hTERT induces cell apoptosis and ERS

Dominant-negative mutants of telomerase hTERT were demonstrated to have selective effects in tumor cells. However, no any effective and highly selective hTERT inhibitor has been developed so far. We focused on developing new hTERT modulators and synthesized a small molecular compound, named (4-bromo...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Cheng, Xiu, Shi, Jing Bo, Liu, Hao, Chen, Liu Zeng, Wang, Yang, Tang, Wen Jian, Liu, Xin Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596570/
https://ncbi.nlm.nih.gov/pubmed/28837145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.384
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