Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses

Aging has a strong impact on the activity of the immune system, enhancing susceptibility to pathogens and provoking a predominant pre-inflammatory status, whereas dampening responses to vaccines in humans and mice. Here, we demonstrate a loss of marginal zone B lymphocytes (MZ, CD19(+)CD45R(+)CD21(+...

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Publicat a:Cell Death Dis
Autors principals: Cortegano, Isabel, Rodríguez, Mercedes, Martín, Isabel, Prado, Maria Carmen, Ruíz, Carolina, Hortigüela, Rafael, Alía, Mario, Vilar, Marçal, Mira, Helena, Cano, Eva, Domínguez, Mercedes, de Andrés, Belén, Gaspar, María Luisa
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596542/
https://ncbi.nlm.nih.gov/pubmed/28817118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.351
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