Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding

Survival of trophoblast cells in the low oxygen environment of human placentation requires metalloproteinase-mediated shedding of HBEGF and downstream signaling. A matrix metalloproteinase (MMP) antibody array and quantitative RT-PCR revealed upregulation of MMP2 post-transcriptionally in human firs...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Jain, Chandni V, Jessmon, Philip, Barrak, Charbel T, Bolnick, Alan D, Kilburn, Brian A, Hertz, Michael, Armant, D Randall
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596420/
https://ncbi.nlm.nih.gov/pubmed/28731464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.104
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