Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We report that senescence alters cellular iron acquisition and storage and also impedes iron-mediated cell death pathways. Senesce...

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Bibliografiske detaljer
Udgivet i:Redox Biol
Main Authors: Masaldan, Shashank, Clatworthy, Sharnel A.S., Gamell, Cristina, Meggyesy, Peter M., Rigopoulos, Antonia-Tonia, Haupt, Sue, Haupt, Ygal, Denoyer, Delphine, Adlard, Paul A., Bush, Ashley I., Cater, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596264/
https://ncbi.nlm.nih.gov/pubmed/28888202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.08.015
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