Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways

MYC activation at modest levels has been frequently found in hepatocellular carcinoma. However, its significance in hepatocarcinogenesis has remained obscure. Here we examined the role of Myc activation in mouse liver tumours induced by hepatocytic expression of myristoylated AKT (AKT) and/or mutant...

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Publicado en:Oncogene
Autores principales: Xin, B, Yamamoto, M, Fujii, K, Ooshio, T, Chen, X, Okada, Y, Watanabe, K, Miyokawa, N, Furukawa, H, Nishikawa, Y
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596209/
https://ncbi.nlm.nih.gov/pubmed/28481866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.114
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