NF-κB upregulation through epigenetic silencing of LDOC1 drives tumor biology and specific immunophenotype in Group A ependymoma

BACKGROUND: Inflammation has been identified as a hallmark of high-risk Group A (GpA) ependymoma (EPN). Chronic interleukin (IL)-6 secretion from GpA tumors drives an immune suppressive phenotype by polarizing infiltrating monocytes. This study determines the mechanism by which IL-6 is dysregulated...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Griesinger, Andrea M, Witt, Davis A, Grob, Sydney T, Georgio Westover, Sabrina R, Donson, Andrew M, Sanford, Bridget, Mulcahy Levy, Jean M, Wong, Randall, Moreira, Daniel C, DeSisto, John A, Balakrishnan, Ilango, Hoffman, Lindsey M, Handler, Michael H, Jones, Kenneth L, Vibhakar, Rajeev, Venkataraman, Sujatha, Foreman, Nicholas K
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Basic and Translational Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596179/
https://ncbi.nlm.nih.gov/pubmed/28510691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox061
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