DNA methylation of a novel PAK4 locus influences ototoxicity susceptibility following cisplatin and radiation therapy for pediatric embryonal tumors

BACKGROUND: Ototoxicity is a common adverse side effect of platinum chemotherapy and cranial radiation therapy; however, individual susceptibility is highly variable. Therefore, our objective was to conduct an epigenome-wide association study to identify differentially methylated cytosine-phosphate-...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Brown, Austin L, Foster, Kayla L, Lupo, Philip J, Peckham-Gregory, Erin C, Murray, Jeffrey C, Okcu, M Fatih, Lau, Ching C, Rednam, Surya P, Chintagumpala, Murali, Scheurer, Michael E
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596178/
https://ncbi.nlm.nih.gov/pubmed/28444219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox076
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