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Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

BACKGROUND: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biol...

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發表在:PLoS Med
Main Authors: Wheeler, Eleanor, Leong, Aaron, Liu, Ching-Ti, Hivert, Marie-France, Strawbridge, Rona J., Podmore, Clara, Li, Man, Yao, Jie, Sim, Xueling, Hong, Jaeyoung, Chu, Audrey Y., Zhang, Weihua, Wang, Xu, Chen, Peng, Maruthur, Nisa M., Porneala, Bianca C., Sharp, Stephen J., Jia, Yucheng, Kabagambe, Edmond K., Chang, Li-Ching, Chen, Wei-Min, Elks, Cathy E., Evans, Daniel S., Fan, Qiao, Giulianini, Franco, Go, Min Jin, Hottenga, Jouke-Jan, Hu, Yao, Jackson, Anne U., Kanoni, Stavroula, Kim, Young Jin, Kleber, Marcus E., Ladenvall, Claes, Lecoeur, Cecile, Lim, Sing-Hui, Lu, Yingchang, Mahajan, Anubha, Marzi, Carola, Nalls, Mike A., Navarro, Pau, Nolte, Ilja M., Rose, Lynda M., Rybin, Denis V., Sanna, Serena, Shi, Yuan, Stram, Daniel O., Takeuchi, Fumihiko, Tan, Shu Pei, van der Most, Peter J., Van Vliet-Ostaptchouk, Jana V., Wong, Andrew, Yengo, Loic, Zhao, Wanting, Goel, Anuj, Martinez Larrad, Maria Teresa, Radke, Dörte, Salo, Perttu, Tanaka, Toshiko, van Iperen, Erik P. A., Abecasis, Goncalo, Afaq, Saima, Alizadeh, Behrooz Z., Bertoni, Alain G., Bonnefond, Amelie, Böttcher, Yvonne, Bottinger, Erwin P., Campbell, Harry, Carlson, Olga D., Chen, Chien-Hsiun, Cho, Yoon Shin, Garvey, W. Timothy, Gieger, Christian, Goodarzi, Mark O., Grallert, Harald, Hamsten, Anders, Hartman, Catharina A., Herder, Christian, Hsiung, Chao Agnes, Huang, Jie, Igase, Michiya, Isono, Masato, Katsuya, Tomohiro, Khor, Chiea-Chuen, Kiess, Wieland, Kohara, Katsuhiko, Kovacs, Peter, Lee, Juyoung, Lee, Wen-Jane, Lehne, Benjamin, Li, Huaixing, Liu, Jianjun, Lobbens, Stephane, Luan, Jian'an, Lyssenko, Valeriya, Meitinger, Thomas, Miki, Tetsuro, Miljkovic, Iva, Moon, Sanghoon, Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Nagaraja, Ramaiah, Nauck, Matthias, Pankow, James S., Polasek, Ozren, Prokopenko, Inga, Ramos, Paula S., Rasmussen-Torvik, Laura, Rathmann, Wolfgang, Rich, Stephen S., Robertson, Neil R., Roden, Michael, Roussel, Ronan, Rudan, Igor, Scott, Robert A., Scott, William R., Sennblad, Bengt, Siscovick, David S., Strauch, Konstantin, Sun, Liang, Swertz, Morris, Tajuddin, Salman M., Taylor, Kent D., Teo, Yik-Ying, Tham, Yih Chung, Tönjes, Anke, Wareham, Nicholas J., Willemsen, Gonneke, Wilsgaard, Tom, Hingorani, Aroon D., Egan, Josephine, Ferrucci, Luigi, Hovingh, G. Kees, Jula, Antti, Kivimaki, Mika, Kumari, Meena, Njølstad, Inger, Palmer, Colin N. A., Serrano Ríos, Manuel, Stumvoll, Michael, Watkins, Hugh, Aung, Tin, Blüher, Matthias, Boehnke, Michael, Boomsma, Dorret I., Bornstein, Stefan R., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chen, Yduan-Tsong, Cheng, Ching-Yu, Cucca, Francesco, de Geus, Eco J. C., Deloukas, Panos, Evans, Michele K., Fornage, Myriam, Friedlander, Yechiel, Froguel, Philippe, Groop, Leif, Gross, Myron D., Harris, Tamara B., Hayward, Caroline, Heng, Chew-Kiat, Ingelsson, Erik, Kato, Norihiro, Kim, Bong-Jo, Koh, Woon-Puay, Kooner, Jaspal S., Körner, Antje, Kuh, Diana, Kuusisto, Johanna, Laakso, Markku, Lin, Xu, Liu, Yongmei, Loos, Ruth J. F., Magnusson, Patrik K. E., März, Winfried, McCarthy, Mark I., Oldehinkel, Albertine J., Ong, Ken K., Pedersen, Nancy L., Pereira, Mark A., Peters, Annette, Ridker, Paul M., Sabanayagam, Charumathi, Sale, Michele, Saleheen, Danish, Saltevo, Juha, Schwarz, Peter EH., Sheu, Wayne H. H., Snieder, Harold, Spector, Timothy D., Tabara, Yasuharu, Tuomilehto, Jaakko, van Dam, Rob M., Wilson, James G., Wilson, James F., Wolffenbuttel, Bruce H. R., Wong, Tien Yin, Wu, Jer-Yuarn, Yuan, Jian-Min, Zonderman, Alan B., Soranzo, Nicole, Guo, Xiuqing, Roberts, David J., Florez, Jose C., Sladek, Robert, Dupuis, Josée, Morris, Andrew P., Tai, E-Shyong, Selvin, Elizabeth, Rotter, Jerome I., Langenberg, Claudia, Barroso, Inês, Meigs, James B.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595282/
https://ncbi.nlm.nih.gov/pubmed/28898252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002383
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