Hemidesmosome integrity protects the colon against colitis and colorectal cancer

OBJECTIVE: Epidemiological and clinical data indicate that patients suffering from IBD with long-standing colitis display a higher risk to develop colorectal high-grade dysplasia. Whereas carcinoma invasion and metastasis rely on basement membrane (BM) disruption, experimental evidence is lacking re...

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Vydáno v:Gut
Hlavní autoři: De Arcangelis, Adèle, Hamade, Hussein, Alpy, Fabien, Normand, Sylvain, Bruyère, Emilie, Lefebvre, Olivier, Méchine-Neuville, Agnès, Siebert, Stéphanie, Pfister, Véronique, Lepage, Patricia, Laquerriere, Patrice, Dembele, Doulaye, Delanoye-Crespin, Anne, Rodius, Sophie, Robine, Sylvie, Kedinger, Michèle, Van Seuningen, Isabelle, Simon-Assmann, Patricia, Chamaillard, Mathias, Labouesse, Michel, Georges-Labouesse, Elisabeth
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2017
Témata:
Inflammatory Bowel Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595104/
https://ncbi.nlm.nih.gov/pubmed/27371534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-310847
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