Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice

BACKGROUND: Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to bone metabolism, its role in OA remains unknown. We therefore investigated the...

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Publicat a:BMC Musculoskelet Disord
Autors principals: Moritake, Akihiro, Kawao, Naoyuki, Okada, Kiyotaka, Tatsumi, Kohei, Ishida, Masayoshi, Okumoto, Katsumi, Matsuo, Osamu, Akagi, Masao, Kaji, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594514/
https://ncbi.nlm.nih.gov/pubmed/28893232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-017-1752-5
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