Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice

BACKGROUND: Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to bone metabolism, its role in OA remains unknown. We therefore investigated the...

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Detalhes bibliográficos
Publicado no:BMC Musculoskelet Disord
Main Authors: Moritake, Akihiro, Kawao, Naoyuki, Okada, Kiyotaka, Tatsumi, Kohei, Ishida, Masayoshi, Okumoto, Katsumi, Matsuo, Osamu, Akagi, Masao, Kaji, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594514/
https://ncbi.nlm.nih.gov/pubmed/28893232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-017-1752-5
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