The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3

Long QT Syndrome 3 (LQTS3) arises from gain-of-function Na(v)1.5 mutations, prolonging action potential repolarisation and electrocardiographic (ECG) QT interval, associated with increased age-dependent risk for major arrhythmic events, and paradoxical responses to β-adrenergic agents. We investigat...

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Vydáno v:Sci Rep
Hlavní autoři: Chadda, Karan R., Ahmad, Shiraz, Valli, Haseeb, den Uijl, Ingrid, Al-Hadithi, Ali BAK, Salvage, Samantha C., Grace, Andrew A., Huang, Christopher L.-H., Jeevaratnam, Kamalan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593918/
https://ncbi.nlm.nih.gov/pubmed/28894151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11210-3
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