Synergistic suppression of t(8;21)-positive leukemia cell growth by combining oridonin and MAPK1/ERK2 inhibitors

One of the most common chromosomal translocations in acute myeloid leukemia is t(8;21)(q22;q22), which results in the appearance of abnormal transcripts encoding for the fusion protein RUNX1-ETO. Therefore, this oncoprotein is considered to be a pertinent and promising target for treating t(8;21) le...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Spirin, Pavel, Lebedev, Timofey, Orlova, Natalia, Morozov, Alexey, Poymenova, Nadezhda, Dmitriev, Sergey E., Buzdin, Anton, Stocking, Carol, Kovalchuk, Olga, Prassolov, Vladimir
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593619/
https://ncbi.nlm.nih.gov/pubmed/28915648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18503
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