Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling

Complex cytoplasmic nucleotide-sensing mechanisms can recognize foreign DNA based on a lack of methylation and initiate an immune response to clear the infection. Zebrafish embryos with global DNA hypomethylation caused by mutations in the ubiquitin-like with PHD and ring finger domains 1 (uhrf1) or...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Chernyavskaya, Yelena, Mudbhary, Raksha, Zhang, Chi, Tokarz, Debra, Jacob, Vinitha, Gopinath, Smita, Sun, Xiaochen, Wang, Shuang, Magnani, Elena, Madakashira, Bhavani P., Yoder, Jeffrey A., Hoshida, Yujin, Sadler, Kirsten C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592811/
https://ncbi.nlm.nih.gov/pubmed/28698226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.147629
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