Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism

Breast cancer cells disseminate through TIE2/MENA(Calc)/MENA(INV)-dependent cancer cell intravasation sites, called tumor microenvironment of metastasis (TMEM), which are clinically validated as prognostic markers of metastasis in breast cancer patients. Using fixed tissue and intravital imaging of...

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Udgivet i:Sci Transl Med
Main Authors: Karagiannis, George S., Pastoriza, Jessica M., Wang, Yarong, Harney, Allison S., Entenberg, David, Pignatelli, Jeanine, Sharma, Ved P., Xue, Emily A., Cheng, Esther, D’Alfonso, Timothy M., Jones, Joan G., Anampa, Jesus, Rohan, Thomas E., Sparano, Joseph A., Condeelis, John S., Oktay, Maja H.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592784/
https://ncbi.nlm.nih.gov/pubmed/28679654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan0026
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