Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis Due to Dysfunction of the Hypothalamic Glucocorticoid Receptor in Sigma-1 Receptor Knockout Mice

Sigma-1 receptor knockout (σ(1)R-KO) mice exhibit a depressive-like phenotype. Because σ(1)R is highly expressed in the neuronal cells of hypothalamic paraventricular nuclei (PVN), this study investigated the influence of σ(1)R deficiency on the regulation of the hypothalamic-pituitary-adrenocortica...

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Bibliographische Detailangaben
Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Di, Tingting, Zhang, Suyun, Hong, Juan, Zhang, Tingting, Chen, Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592243/
https://ncbi.nlm.nih.gov/pubmed/28932185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00287
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