Indomethacin Increases Neurogenesis across Age Groups and Improves Delayed Probe Trial Difference Scores in Middle-Aged Rats

We tested whether indomethacin or rosiglitazone treatment could rejuvenate spatial ability and hippocampal neurogenesis in aging rats. Young (4 mo; n = 30), middle-aged (12 mo; n = 31), and aged (18 mo; n = 31) male Fischer 344 rats were trained and then tested in a rapid acquisition water maze task...

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Publicado en:Front Aging Neurosci
Autores principales: McGuiness, James A., Scheinert, Rachel B., Asokan, Aditya, Stadler, Vivien-Charlott, Lee, Christian S., Rani, Asha, Kumar, Ashok, Foster, Thomas C., Ormerod, Brandi K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591789/
https://ncbi.nlm.nih.gov/pubmed/28928652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00280
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