CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency

The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. WHIM patient adaptive immunity defects remain largely unexplained. We have previously shown that WHIM-mutant T cells form unstable immunological synapse...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Roselli, Giuliana, Martini, Elisa, Lougaris, Vassilios, Badolato, Raffaele, Viola, Antonella, Kallikourdis, Marinos
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591327/
https://ncbi.nlm.nih.gov/pubmed/28928741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01068
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