CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency

The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. WHIM patient adaptive immunity defects remain largely unexplained. We have previously shown that WHIM-mutant T cells form unstable immunological synapse...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Roselli, Giuliana, Martini, Elisa, Lougaris, Vassilios, Badolato, Raffaele, Viola, Antonella, Kallikourdis, Marinos
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591327/
https://ncbi.nlm.nih.gov/pubmed/28928741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01068
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