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Urban PM2.5 exacerbates allergic inflammation in the murine lung via a TLR2/TLR4/MyD88-signaling pathway

Nevertheless its mechanism has not been well explained yet, PM2.5 is recognized to exacerbate asthma. In the present study, the roles of toll-like receptor (TLR) 2, TLR4 and MyD88, in exacerbation of allergen-induced lung eosinophilia caused by urban PM2.5 was investigated. TLR2-, TLR4-, MyD88-defic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: He, Miao, Ichinose, Takamichi, Yoshida, Yasuhiro, Arashidani, Keiichi, Yoshida, Seiichi, Takano, Hirohisa, Sun, Guifan, Shibamoto, Takayuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591243/
https://ncbi.nlm.nih.gov/pubmed/28887522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11471-y
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