Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade

Immune checkpoint blockade is able to achieve durable responses in a subset of patients, however we lack a satisfying comprehension of the underlying mechanisms of anti-CTLA-4 and anti-PD-1 induced tumor rejection. To address these issues we utilized mass cytometry to comprehensively profile the eff...

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Veröffentlicht in:Cell
Hauptverfasser: Wei, Spencer C., Levine, Jacob H., Cogdill, Alexandria P., Zhao, Yang, Anang, Nana-Ama A.S., Andrews, Miles C., Sharma, Padmanee, Wang, Jing, Wargo, Jennifer A., Pe'er, Dana, Allison, James P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591072/
https://ncbi.nlm.nih.gov/pubmed/28803728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.024
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