Prospective replication study implicates the catechol-O-methyltransferase Val(158)Met polymorphism as a biomarker for the response to morphine in patients with cancer

Genetic differences in humans cause clinical difficulties in opioid treatment. Previous studies indicate that a single nucleotide polymorphism in the catechol-O-methyltransferase (COMT) gene (rs4680; p.Val(158)Met) may present as a predictive biomarker for the response to morphine treatment. In our...

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Udgivet i:Biomed Rep
Main Authors: Matsuoka, Hiromichi, Makimura, Chihiro, Koyama, Atsuko, Fujita, Yoshihiko, Tsurutani, Junji, Sakai, Kiyohiro, Sakamoto, Ryo, Nishio, Kazuto, Nakagawa, Kazuhiko
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590034/
https://ncbi.nlm.nih.gov/pubmed/28928973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/br.2017.963
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