The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells

Disruption of nasal epithelial tight junctions (TJs) and ciliary dysfunction are found in patients with chronic rhinosinusitis (CRS) and nasal polyps (NPs), along with an increase of p63-positive basal cells and histone deacetylase (HDAC) activity. To investigate these mechanisms, primary cultures o...

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Publicado no:Sci Rep
Main Authors: Kaneko, Yakuto, Kohno, Takayuki, Kakuki, Takuya, Takano, Ken-ichi, Ogasawara, Noriko, Miyata, Ryo, Kikuchi, Shin, Konno, Takumi, Ohkuni, Tsuyoshi, Yajima, Ryoto, Kakiuchi, Akito, Yokota, Shin-ichi, Himi, Tetsuo, Kojima, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589951/
https://ncbi.nlm.nih.gov/pubmed/28883651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11481-w
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