Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions

Protein-based biosensors or activators have been engineered to visualize molecular signals or manipulate cellular functions. Here we integrate these two functionalities into one protein molecule, an integrated sensing and activating protein (iSNAP). A prototype that can detect tyrosine phosphorylati...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sun, Jie, Lei, Lei, Tsai, Chih-Ming, Wang, Yi, Shi, Yiwen, Ouyang, Mingxing, Lu, Shaoying, Seong, Jihye, Kim, Tae-Jin, Wang, Pengzhi, Huang, Min, Xu, Xiangdong, Nizet, Victor, Chien, Shu, Wang, Yingxiao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589908/
https://ncbi.nlm.nih.gov/pubmed/28883531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00569-6
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