Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

Nonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to hepatic fatty acid accumulation. Here, we show that the Fas cell surface death r...

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Udgivet i:Nat Commun
Main Authors: Item, Flurin, Wueest, Stephan, Lemos, Vera, Stein, Sokrates, Lucchini, Fabrizio C., Denzler, Rémy, Fisser, Muriel C., Challa, Tenagne D., Pirinen, Eija, Kim, Youngsoo, Hemmi, Silvio, Gulbins, Erich, Gross, Atan, O’Reilly, Lorraine A., Stoffel, Markus, Auwerx, Johan, Konrad, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589858/
https://ncbi.nlm.nih.gov/pubmed/28883393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00566-9
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