Adaptive mutations of neuraminidase stalk truncation and deglycosylation confer enhanced pathogenicity of influenza A viruses

It has been noticed that neuraminidase (NA) stalk truncation has arisen from evolutionary adaptation of avian influenza A viruses (IAVs) from wild aquatic birds to domestic poultry. We identified this molecular alteration after the adaptation of a 2009 pandemic H1N1 virus (pH1N1) in BALB/c mice. The...

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Udgivet i:Sci Rep
Main Authors: Park, Sehee, Il Kim, Jin, Lee, Ilseob, Bae, Joon-Yong, Yoo, Kirim, Nam, Misun, Kim, Juwon, Sook Park, Mee, Song, Ki-Joon, Song, Jin-Won, Kee, Sun-Ho, Park, Man-Seong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589767/
https://ncbi.nlm.nih.gov/pubmed/28883554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11348-0
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