Acetyl-lupeolic acid inhibits Akt signaling and induces apoptosis in chemoresistant prostate cancer cells in vitro and in vivo

The triterpenoid acetyl-lupeolic acid (ac-LA) isolated from the oleogum resin of Boswellia carterii reduced the viability of a panel of cancer cell lines more efficiently than lupeol. There was no detectable intracellular conversion of ac-LA to lupeol and vice versa. In contrast to docetaxel, ac-LA...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Schmidt, Claudia, Loos, Cornelia, Jin, Lu, Schmiech, Michael, Schmidt, Christoph Q., Gaafary, Menna El, Syrovets, Tatiana, Simmet, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589648/
https://ncbi.nlm.nih.gov/pubmed/28903409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19101
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