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Dissection of mammalian orthoreovirus µ2 reveals a self-associative domain required for binding to microtubules but not to factory matrix protein µNS

Mammalian orthoreovirus protein μ2 is a component of the viral core particle. Its activities include RNA binding and hydrolysis of the γ-phosphate from NTPs and RNA 5´-termini, suggesting roles as a cofactor for the viral RNA-dependent RNA polymerase, λ3, first enzyme in 5´-capping of viral plus-str...

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Publicado en:PLoS One
Autores principales: Eichwald, Catherine, Kim, Jonghwa, Nibert, Max L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589220/
https://ncbi.nlm.nih.gov/pubmed/28880890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184356
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