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Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid

First-principles quantum mechanical/molecular mechanical (QM/MM)-free energy calculations have been performed to uncover how uricase catalyzes metabolic reactions of uric acid (UA), demonstrating that the entire reaction process of UA in uricase consists of two stages–oxidation followed by hydration...

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Detalhes bibliográficos
Publicado no:ACS Catal
Main Authors: Wei, Donghui, Huang, Xiaoqin, Qiao, Yan, Rao, Jingjing, Wang, Lu, Liao, Fei, Zhan, Chang-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589204/
https://ncbi.nlm.nih.gov/pubmed/28890842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.7b00901
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