LAG-3 potentiates the survival of Mycobacterium tuberculosis in host phagocytes by modulating mitochondrial signaling in an in-vitro granuloma model

CD4(+) T-cell mediated Th1 immune responses are critical for immunity to TB. The immunomodulatory protein, lymphocyte activation gene-3 (LAG-3) decreases Th1-type immune responses in T-cells. LAG-3 expression is significantly induced in the lungs of macaques with active TB and correlates with increa...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Phillips, Bonnie L., Gautam, Uma S., Bucsan, Allison N., Foreman, Taylor W., Golden, Nadia A., Niu, Tianhua, Kaushal, Deepak, Mehra, Smriti
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589099/
https://ncbi.nlm.nih.gov/pubmed/28880895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180413
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