Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology

BACKGROUND: Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investigate the...

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Bibliografische gegevens
Gepubliceerd in:Genes Nutr
Hoofdauteurs: Miousse, Isabelle R., Pathak, Rupak, Garg, Sarita, Skinner, Charles M., Melnyk, Stepan, Pavliv, Oleksandra, Hendrickson, Howard, Landes, Reid D., Lumen, Annie, Tackett, Alan J., Deutz, Nicolaas E.P., Hauer-Jensen, Martin, Koturbash, Igor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2017
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588631/
https://ncbi.nlm.nih.gov/pubmed/28904640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12263-017-0576-0
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